Human MAT2B Recombinant Protein (RPPB1926)
- SKU:
- RPPB1926
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NZL9
- Research Area:
- Enzymes
Description
| Product Name: | Human MAT2B Recombinant Protein |
| Product Code: | RPPB1926 |
| Size: | 20µg |
| Species: | Human |
| Target: | MAT2B |
| Synonyms: | MAT2-beta, MAT-2B, MAT2-B, DTDP-4-keto-6-deoxy-D-glucose 4-reductase, MAT-II, MATIIbeta, MAT II beta, Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, MGC12237, MSTP045, Nbla02999, SDR23E1, TGR, UNQ2435/PRO4995, MAT2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The MAT2B protein solution contains 20mM Tris-HCl, pH-8, 1mM DTT, 1mM EDTA and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MPEMPEDMEQ EEVNIPNRRV LVTGATGLLG RAVHKEFQQN NWHAVGCGFR RARPKFEQVN LLDSNAVHHI IHDFQPHVIV HCAAERRPDV VENQPDAASQ LNVDASGNLA KEAAAVGAFL IYISSDYVFD GTNPPYREED IPAPLNLYGK TKLDGEKAVL ENNLGAAVLR IPILYGEVEK LEESAVTVMF DKVQFSNKSA NMDHWQQRFP THVKDVATVC RQLAEKRMLD PSIKGTFHWS GNEQMTKYEM ACAIADAFNL PSSHLRPITD SPVLGAQRPR NTQLDCSKLE TLGIGQRTPF RIGIKESLWP FLIDKRWRQT VFH |
MAT2B is part of the methionine adenosyltransferase family. MAT2B catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. MAT2B is the regulatory beta subunit of MAT. MAT2B expression in hepatoma cell lines increases DNA synthesis and thus take part in cell proliferation.
Recombinant Human MAT2B produced in E.Coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (1-323 a.a) and having a molecular mass of 36.4 kDa. MAT2B is is purified by conventional chromatography techniques.
| UniProt Protein Function: | MAT2B: Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition. Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine Chromosomal Location of Human Ortholog: 5q34 Cellular Component: methionine adenosyltransferase complex; mitochondrion; intracellular; cytosol; nucleus Molecular Function:enzyme binding; methionine adenosyltransferase regulator activity Biological Process: methylation; regulation of catalytic activity; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process |
| NCBI Summary: | The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
| UniProt Code: | Q9NZL9 |
| NCBI GenInfo Identifier: | 74719662 |
| NCBI Gene ID: | 27430 |
| NCBI Accession: | Q9NZL9.1 |
| UniProt Secondary Accession: | Q9NZL9,Q1WAI7, Q27J92, Q3LIE8, Q567T7, Q6NYC7, Q9BS89 Q9H3E1, Q9UJ54, B2R5Y6, |
| UniProt Related Accession: | Q9NZL9 |
| Molecular Weight: | 334 |
| NCBI Full Name: | Methionine adenosyltransferase 2 subunit beta |
| NCBI Synonym Full Names: | methionine adenosyltransferase II, beta |
| NCBI Official Symbol: | MAT2B�� |
| NCBI Official Synonym Symbols: | TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999�� |
| NCBI Protein Information: | methionine adenosyltransferase 2 subunit beta; MAT II beta; putative protein product of Nbla02999; dTDP-4-keto-6-deoxy-D-glucose 4-reductase; putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; short chain dehydrogenase/reductase family 23E, member 1; bet |
| UniProt Protein Name: | Methionine adenosyltransferase 2 subunit beta |
| UniProt Synonym Protein Names: | Methionine adenosyltransferase II beta; MAT II beta; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase |
| Protein Family: | Methionine adenosyltransferase |
| UniProt Gene Name: | MAT2B�� |
| UniProt Entry Name: | MAT2B_HUMAN |
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