Description
| Product Name: | Human NUP210 Recombinant Protein |
| Product Code: | RPPB4140 |
| Size: | 20µg |
| Species: | Human |
| Target: | NUP210 |
| Synonyms: | Nucleoporin 210kDa, KIAA0906, GP210, Nuclear envelope pore membrane protein POM 210, Nuclear pore protein gp210, nuclear pore membrane glycoprotein 210. |
| Source: | Sf9 Insect cells |
| Formulation: | NUP210 is supplied in 20mM HEPES buffer pH-7.9 and 6M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
The NUP210 complex is a immense structure which spreads through the nuclear envelope, forming a doorway which regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the core components of the nuclear pore complex in eukaryotic cells. NUP210 is a membrane-spanning glycoprotein and is a major component of the nuclear pore complex.
Recombinant NUP210 protein is a construct carrying multiple concatenated copies of the short cytoplasmic gp210 C-terminus (which contains the autoreactive epitopes) and having a molecular mass of 27kDa (pH 9.8). NUP210 protein is fused to a hexa-histidine purification tag.
| UniProt Protein Function: | NUP210: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. Belongs to the NUP210 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleoporin; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: membrane; nuclear envelope; nuclear pore Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein sumoylation; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription |
| NCBI Summary: | The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q8TEM1 |
| NCBI GenInfo Identifier: | 116242720 |
| NCBI Gene ID: | 23225 |
| NCBI Accession: | Q8TEM1.3 |
| UniProt Secondary Accession: | Q8TEM1,O94980, Q6NXG6, Q8NBJ1, Q9H6C8, Q9UFP3, A6NN56 |
| UniProt Related Accession: | Q8TEM1 |
| Molecular Weight: | 105,810 Da |
| NCBI Full Name: | Nuclear pore membrane glycoprotein 210 |
| NCBI Synonym Full Names: | nucleoporin 210 |
| NCBI Official Symbol: | NUP210�� |
| NCBI Official Synonym Symbols: | GP210; POM210�� |
| NCBI Protein Information: | nuclear pore membrane glycoprotein 210 |
| UniProt Protein Name: | Nuclear pore membrane glycoprotein 210 |
| UniProt Synonym Protein Names: | Nuclear envelope pore membrane protein POM 210; POM210; Nucleoporin Nup210; Pore membrane protein of 210 kDa |
| Protein Family: | Nuclear pore membrane glycoprotein |
| UniProt Gene Name: | NUP210�� |
| UniProt Entry Name: | PO210_HUMAN |
