Human OLR1 Recombinant Protein (RPPB4156)
- SKU:
- RPPB4156
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P78380
Description
| Product Name: | Human OLR1 Recombinant Protein |
| Product Code: | RPPB4156 |
| Size: | 10µg |
| Species: | Human |
| Target: | OLR1 |
| Synonyms: | OxidizedLow Density Lipoprotein Receptor 1, C-Type Lectin Domain Family 8 Member A, Lectin-TypeOxidized LDL Receptor 1, CLEC8A, HLOX-1, LOX1, Oxidised Low Density Lipoprotein(Lectin-Like) Receptor 1, Oxidized Low Density Lipoprotein (Lectin-Like)Receptor 1, Oxidized Low-Density Lipoprotein Receptor 1, Soluble Form, OxidizedLow-Density Lipoprotein Receptor 1, Scavenger Receptor Class E, Member 1, Lectin-LikeOxidized LDL Receptor 1, Lectin-Like OxLDL Receptor 1, Ox LDL Receptor 1, Ox-LDLReceptor 1, SCARE1, LOXIN, SLOX1, LOX-1, Oxidized low-density lipoproteinreceptor 1, Ox-LDL receptor 1, C-type lectin domain family 8 member A, LOX-1, Lectin-likeoxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | OLR1protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10%glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPMQLSQVSDLLTQEQANL THQKKKLEGQ ISARQQAEEA SQESENELKE MIETLARKLN EKSKEQMELH HQNLNLQETLKRVANCSAPC PQDWIWHGEN CYLFSSGSFN WEKSQEKCLS LDAKLLKINS TADLDFIQQA ISYSSFPFWMGLSRRNPSYP WLWEDGSPLM PHLFRVRGAVSQTYPSGTCA YIQRGAVYAE NCILAAFSIC QKKANLRAQH HHHHH |
OLR1 is a type II membrane protein which belongs to the C-type lectin family and performs as a cell-surface receptor for Ox-LDL. Ox-LDL has a part in early ather-osclerosis, which includes the transformation of monocyte-derived macro-phages to foam cells in atherosclerotic lesions. In addition, OLR1 protein triggers the activation of the NFkB signal transduction pathway.
OLR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 225 amino acids (58-273a.a) and having a molecular mass of 25.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). OLR1 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OLR1: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria. Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility. OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 12p13.2-p12.3 Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; receptor complex; lipid raft Molecular Function:low-density lipoprotein receptor activity; protein binding; carbohydrate binding Biological Process: cell death; receptor-mediated endocytosis; leukocyte adhesion; response to hydrogen peroxide; blood circulation; lipoprotein metabolic process; inflammatory response; proteolysis; blood coagulation; leukocyte migration Disease: Myocardial Infarction, Susceptibility To |
| NCBI Summary: | This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
| UniProt Code: | P78380 |
| NCBI GenInfo Identifier: | 73621335 |
| NCBI Gene ID: | 4973 |
| NCBI Accession: | P78380.1 |
| UniProt Secondary Accession: | P78380,Q2PP00, Q7Z484, A8K7V9, B4DI48, G3V1I4, |
| UniProt Related Accession: | P78380 |
| Molecular Weight: | 21,425 Da |
| NCBI Full Name: | Oxidized low-density lipoprotein receptor 1 |
| NCBI Synonym Full Names: | oxidized low density lipoprotein (lectin-like) receptor 1 |
| NCBI Official Symbol: | OLR1�� |
| NCBI Official Synonym Symbols: | LOX1; LOXIN; SLOX1; CLEC8A; SCARE1�� |
| NCBI Protein Information: | oxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type lectin domain family 8 member A; oxidized low-density lipoprotein receptor 1, soluble form |
| UniProt Protein Name: | Oxidized low-density lipoprotein receptor 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1Cleaved into the following chain:Oxidized low-density lipoprotein receptor 1, soluble form |
| Protein Family: | Oxidized low-density lipoprotein receptor |
| UniProt Gene Name: | OLR1�� |
| UniProt Entry Name: | OLR1_HUMAN |
