Description
| Product Name: | Human PELI2 Recombinant Protein |
| Product Code: | RPPB4224 |
| Size: | 10µg |
| Species: | Human |
| Target: | PELI2 |
| Synonyms: | Pellino E3 Ubiquitin Protein Ligase Family Member 2, Pellino-2,E3 Ubiquitin-Protein Ligase Pellino Homolog 2, Pellino (Drosophila) Homolog 2, PellinoHomolog 2 (Drosophila), Protein Pellino Homolog 2, Pellino Homolog 2, EC 6.3.2,PELI2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PELI2 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMFSPGQE EHCAPNKEPV KYGELVVLGY NGALPNGDRG RRKSRFALYKRPKANGVKPS TVHVISTPQA SKAISCKGQH SISYTLSRNQ TVVVEYTHDK DTDMFQVGRS TESPIDFVVTDTISGSQNTD EAQITQSTIS RFACRIVCDR NEPYTARIFA AGFDSSKNIF LGEKAAKWKN PDGHMDGLTT NGVLVMHPRG GFTEESQPGVWREISVCGDV YTLRETRSAQ QRGKLVESET NVLQDGSLID LCGATLLWRT ADGLFHTPTQ KHIEALRQEINAARPQCPVG LNTLAFPSIN RKEVVEEKQP WAYLSCGHVH GYHNWGHRSD TEANERECPM CRTVGPYVPL WLGCEAGFYV DAGPPTHAFT PCGHVCSEKS AKYWSQIPLPHGTHAFHAAC PFCATQLVGE QNCIKLIFQG PID |
| UniProt Code: | Q9HAT8 |
Pellino E3 Ubiquitin Protein Ligase Family Member 2, also known as PELI2is an E3 ubiquitin ligase which catalyzes the covalent attachment of ubiquitinmoieties onto substrate proteins. PELI2 is implicated in the TLR and IL-1signaling pathways through interaction with the complex which contain IRAKkinases and TRAF6. PELI2 also mediates IL1B-induced IRAK1 'Lys-63'-linkedpolyubiquitination and possibly 'Lys-48'-linked ubiquitination. PELI2 is significantfor LPS- and IL1B-induced MAP3K7-dependent, however not for MAP3K3-dependent,NF-kappa-B activation. Moreover, PELI2 can activate the MAP (mitogen activatedprotein) kinase pathway directing to activation of ELK1.
PELI2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 443 amino acids (1-420 a.a) andhaving a molecular mass of 48.8kDa.�PELI2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
