Human PEPD Recombinant Protein (RPPB2092)
- SKU:
- RPPB2092
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P12955
- Research Area:
- Enzymes
Frequently bought together:
Description
| Product Name: | Human PEPD Recombinant Protein |
| Product Code: | RPPB2092 |
| Size: | 20µg |
| Species: | Human |
| Target: | PEPD |
| Synonyms: | Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Peptidase D, Proline dipeptidase, Prolidase, PRD, PEPD, Xaa-Pro dipeptidase isoform 1, PROLIDASE. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PEPD protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSHMGSMAAATGP SFWLGNETLK VPLALFALNR QRLCERLRKN PAVQAGSIVV LQGGEETQRY CTDTGVLFRQESFFHWAFGV TEPGCYGVID VDTGKSTLFV PRLPASHATW MGKIHSKEHF KEKYAVDDVQ YVDEIASVLTSQKPSVLLTL RGVNTDSGSVCREASFDGIS KFEVNNTILH PEIVECRVFK TDMELEVLRYTNKISSEAHR EVMKAVKVGM KEYELESLFE HYCYSRGGMR HSSYTCICGS GENSAVLHYG HAGAPNDRTIQNGDMCLFDM GGEYYCFASD ITCSFPANGK FTADQKAVYE AVLRSSRAVM GAMKPGVWWP DMHRLADRIH LEELAHMGILSGSVDAMVQA HLGAVFMPHG LGHFLGIDVH DVGGYPEGVE RIDEPGLRSL RTARHLQPGM VLTVEPGIYFIDHLLDEALA DPARASFLNR EVLQRFRGFG GVRIEEDVVV TDSGIELLTC VPRTVEEIEA CMAGCDKAFTPFSGPK |
Peptidase D, also known as PEPD, Is a part of the peptidase family. PEPD is involved in collagen metabolism due to the high level of iminoacids in collagen. PEPD recycles proline, and sets the pace for the production of collagen. PEPD is also parts dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position.
PEPD Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 516 amino acids (1-493a.a.) and having a molecular mass of 56.9kDa.PEPD is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | peptidase D: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Defects in PEPD are a cause of prolidase deficiency (PD). Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait. Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.13.9; Protease Chromosomal Location of Human Ortholog: 19q13.11 Molecular Function:dipeptidase activity; manganese ion binding; aminopeptidase activity; metallocarboxypeptidase activity Biological Process: amino acid metabolic process; collagen catabolic process; proteolysis Disease: Prolidase Deficiency |
| NCBI Summary: | This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P12955 |
| NCBI GenInfo Identifier: | 50403718 |
| NCBI Gene ID: | 5184 |
| NCBI Accession: | P12955.3 |
| UniProt Secondary Accession: | P12955,Q8TBN9, Q9BT75, A8K3Z1, A8K416, A8K696, A8MX47 B4DDB7, B4DGJ1, E9PCE8, |
| UniProt Related Accession: | P12955 |
| Molecular Weight: | 493 |
| NCBI Full Name: | Xaa-Pro dipeptidase |
| NCBI Synonym Full Names: | peptidase D |
| NCBI Official Symbol: | PEPD�� |
| NCBI Official Synonym Symbols: | PROLIDASE�� |
| NCBI Protein Information: | xaa-Pro dipeptidase; imidodipeptidase; X-Pro dipeptidase; proline dipeptidase; aminoacyl-L-proline hydrolase |
| UniProt Protein Name: | Xaa-Pro dipeptidase |
| UniProt Synonym Protein Names: | Imidodipeptidase; Peptidase D; Proline dipeptidase; Prolidase |
| Protein Family: | Dipeptidase |
| UniProt Gene Name: | PEPD�� |
| UniProt Entry Name: | PEPD_HUMAN |
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