Human PGAM2 Recombinant Protein (RPPB2098)
- SKU:
- RPPB2098
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15259
- Research Area:
- Enzymes
Description
| Product Name: | Human PGAM2 Recombinant Protein |
| Product Code: | RPPB2098 |
| Size: | 10µg |
| Species: | Human |
| Target: | PGAM2 |
| Synonyms: | Phosphoglycerate mutase 2, BPG-dependent PGAM 2, Muscle-specific phosphoglycerate mutase, Phosphoglycerate mutase isozyme M, PGAM-M, PGAM2, PGAMM, GSD10. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PGAM2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MATHRLVMVR HGESTWNQEN RFCGWFDAEL SEKGTEEAKR GAKAIKDAKM EFDICYTSVL KRAIRTLWAI LDGTDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEE QVKIWRRSFD IPPPPMDEKH PYYNSISKER RYAGLKPGEL PTCESLKDTI ARALPFWNEE IVPQIKAGKR VLIAAHGNSL RGIVKHLEGM SDQAIMELNL PTGIPIVYEL NKELKPTKPM QFLGDEETVR KAMEAVAAQG KAK |
| Biological Activity: | Specific activity is > 100units/mg, in which One unitwill convert 1.0 umole of 3-phosphoglycerate to 2-phosphoglcerate per minute atpH 7.6 at 37C. |
Phosphoglycerate mutase 2 (PGAM2) is a member of the phosphoglycerate mutase family. PGAM is a dimeric enzyme which contains in separate tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). PGAM (Phosphoglycerate mutase) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. PGAM2 gene mutations cause muscle phosphoglycerate mutase efficiency, otherwise known as glycogen storage disease X.
PGAM2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 273 amino acids (1-253) and having a molecular mass of 30.9kDa.PGAM2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Code: | P15259 |
| NCBI GenInfo Identifier: | 50593010 |
| NCBI Gene ID: | 5224 |
| NCBI Accession: | NP_000281.2 |
| UniProt Related Accession: | P15259 |
| Molecular Weight: | 28,766 Da |
| NCBI Full Name: | phosphoglycerate mutase 2 |
| NCBI Synonym Full Names: | phosphoglycerate mutase 2 |
| NCBI Official Symbol: | PGAM2�� |
| NCBI Official Synonym Symbols: | GSD10; PGAMM; PGAM-M�� |
| NCBI Protein Information: | phosphoglycerate mutase 2 |
| UniProt Protein Name: | Phosphoglycerate mutase 2 |
| UniProt Synonym Protein Names: | BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M; PGAM-M |
| Protein Family: | Phosphoglycerate mutase |
| UniProt Gene Name: | PGAM2�� |
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