Human PTP4A1 Recombinant Protein (RPPB2224)
- SKU:
- RPPB2224
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q93096
- Research Area:
- Enzymes
Description
| Product Name: | Human PTP4A1 Recombinant Protein |
| Product Code: | RPPB2224 |
| Size: | 20µg |
| Species: | Human |
| Target: | PTP4A1 |
| Synonyms: | Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1, HH72, DKFZp779M0721. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PTP4A1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC |
Protein tyrosine phosphatase type IVA 1 (PTP4A1) is a cell signaling molecule that has regulatory roles in a variety of cellular processes. PTP4A1 is a unique nuclear PTP which is induced in regenerating liver and mitogen stimulated cells. PTP4A1 is primarily expressed in the spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines.
PTP4A1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 190 amino acids (1-170 a.a.) and having a molecular mass of 21.6kDa. The PTP4A1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PTP4A1: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. Belongs to the protein-tyrosine phosphatase family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 6q12 Cellular Component: cytoplasm; internal side of plasma membrane; nucleus Molecular Function:protein tyrosine phosphatase activity Biological Process: positive regulation of cell migration |
| NCBI Summary: | This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q93096 |
| NCBI GenInfo Identifier: | 68566217 |
| NCBI Gene ID: | 7803 |
| NCBI Accession: | Q93096.2 |
| UniProt Secondary Accession: | Q93096,O00648, Q49A54, B2R6C8, |
| UniProt Related Accession: | Q93096 |
| Molecular Weight: | 19,815 Da |
| NCBI Full Name: | Protein tyrosine phosphatase type IVA 1 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase type IVA, member 1 |
| NCBI Official Symbol: | PTP4A1�� |
| NCBI Official Synonym Symbols: | HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)�� |
| NCBI Protein Information: | protein tyrosine phosphatase type IVA 1 |
| UniProt Protein Name: | Protein tyrosine phosphatase type IVA 1 |
| UniProt Synonym Protein Names: | PTP(CAAXI); Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PRL-1 |
| Protein Family: | Protein tyrosine phosphatase |
| UniProt Gene Name: | PTP4A1�� |
| UniProt Entry Name: | TP4A1_HUMAN |
