Human PTP4A2 Recombinant Protein (RPPB2225)
- SKU:
- RPPB2225
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q12974
- Research Area:
- Enzymes
Description
| Product Name: | Human PTP4A2 Recombinant Protein |
| Product Code: | RPPB2225 |
| Size: | 10µg |
| Species: | Human |
| Target: | PTP4A2 |
| Synonyms: | HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, ptp-IV1a, ptp-IV1b, PTP4A, PTPCAAX2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The PTP4A2 (0.5mg/ml) protein solution contains 20mM Tris-HCl, pH-8, 1mM EDTA and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNRP APVEISYENM RFLITHNPTN ATLNKFTEEL KKYGVTTLVR VCDATYDKAPVEKEGIHVLD WPFDDGAPPP NQIVDDWLNL LKTKFREEPG CCVAVHCVAG LGRAPVLVAL ALIECGMKYE DAVQFIRQKR RGAFNSKQLL YLEKYRPKMR LRFRDTNGHC CVQ |
PTP4A2 is part of a small class of the protein tyrosine phosphatase (PTP) family. PTP4A2 is localized to the early endosome that take part in a variety of cellular activities. PTP4A2 protein interacts with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), therefore has a role as a regulator of GGT II activity. Overexpression of PTP4A2 in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis.
Recombinant Human PTP4A2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 203 amino acids (1-167 a.a.) and having a molecular mass of 23.2 kDa. PTP4A2 is fused to a 36 amino acid His-Tag at N-Terminus and purified by conventional chromatography techniques.
| UniProt Protein Function: | PTP4A2: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p35 Cellular Component: cytoplasm; nucleus Molecular Function:prenylated protein tyrosine phosphatase activity |
| NCBI Summary: | The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q12974 |
| NCBI GenInfo Identifier: | 68566159 |
| NCBI Gene ID: | 8073 |
| NCBI Accession: | Q12974.1 |
| UniProt Secondary Accession: | Q12974,O00649, Q15197, Q15259, Q15260, Q15261, A8K9I8 B4DM39, D3DPP0, E9PGJ6, R4GN50, |
| UniProt Related Accession: | Q12974 |
| Molecular Weight: | 16,367 Da |
| NCBI Full Name: | Protein tyrosine phosphatase type IVA 2 |
| NCBI Synonym Full Names: | protein tyrosine phosphatase type IVA, member 2 |
| NCBI Official Symbol: | PTP4A2�� |
| NCBI Official Synonym Symbols: | HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b�� |
| NCBI Protein Information: | protein tyrosine phosphatase type IVA 2 |
| UniProt Protein Name: | Protein tyrosine phosphatase type IVA 2 |
| UniProt Synonym Protein Names: | HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2 |
| Protein Family: | Protein tyrosine phosphatase |
| UniProt Gene Name: | PTP4A2�� |
| UniProt Entry Name: | TP4A2_HUMAN |
