Description
| Product Name: | Human RAB5B Recombinant Protein |
| Product Code: | RPPB4369 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAB5B |
| Synonyms: | Ras-related protein Rab-5B, RAB5B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAB5B solution (1 mg/ml), 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 20% glycerol and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTSRSTA RPNGQPQASK ICQFKLVLLG ESAVGKSSLV LRFVKGQFHE YQESTIGAAF LTQSVCLDDT TVKFEIWDTA GQERYHSLAP MYYRGAQAAI VVYDITNQET FARAKTWVKE LQRQASPSIV IALAGNKADL ANKRMVEYEE AQAYADDNSL LFMETSAKTA MNVNDLFLAI AKKLPKSEPQ NLGGAAGRSR GVDLHEQSQQ NKSQCCSN |
Ras-related protein Rab-5B (RAB5B) belongs to the Rab family of small (monomeric) G proteins. RAB5B is involved in endocytosis and recycling of cell surface molecules. RAB5B interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of RAB5B abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection.
RAB5B Human Recombinant fused with a 23 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 238 amino acids (1-215 a.a.) and having a molecular mass of 26.1kDa. The RAB5B is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB5B: Protein transport. Probably involved in vesicular traffic. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein; G protein, monomeric, Rab; G protein, monomeric Chromosomal Location of Human Ortholog: 12q13 Cellular Component: membrane; endocytic vesicle; early endosome membrane; early endosome; plasma membrane; melanosome; intracellular; endosome Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; GTP-dependent protein binding Biological Process: antigen processing and presentation; intracellular protein transport; endosome organization and biogenesis; metabolic process; regulation of endocytosis; plasma membrane to endosome transport; Rab protein signal transduction |
| UniProt Code: | P61020 |
| NCBI GenInfo Identifier: | 46577637 |
| NCBI Gene ID: | 5869 |
| NCBI Accession: | P61020.1 |
| UniProt Related Accession: | P61020 |
| Molecular Weight: | |
| NCBI Full Name: | Ras-related protein Rab-5B |
| NCBI Synonym Full Names: | RAB5B, member RAS oncogene family |
| NCBI Official Symbol: | RAB5B�� |
| NCBI Protein Information: | ras-related protein Rab-5B |
| UniProt Protein Name: | Ras-related protein Rab-5B |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB5B�� |
| UniProt Entry Name: | RAB5B_HUMAN |
