Description
| Product Name: | Human RPS7 Recombinant Protein |
| Product Code: | RPPB4512 |
| Size: | 10µg |
| Species: | Human |
| Target: | RPS7 |
| Synonyms: | Ribosomal protein S7, DBA8, S7, 40S ribosomal protein S7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RPS7 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 1mM DTT and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMFSSSA KIVKPNGEKP DEFESGISQA LLELEMNSDL KAQLRELNIT AAKEIEVGGG RKAIIIFVPV PQLKSFQKIQ VRLVRELEKK FSGKHVVFIA QRRILPKPTR KSRTKNKQKR PRSRTLTAVH DAILEDLVFP SEIVGKRIRV KLDGSRLIKV HLDKAQQNNV EHKVETFSGV YKKLTGKDVN FEFPEFQL |
RPS7 is a member of the S3P family of ribosomal proteins and is situated in the cytoplasm. RPS7 takes part in ribosomal stress, connecting ribosome biogenesis to cell death or cell cycle arrest. In addition, RPS7 cooperates with MDM2 and negatively regulate the MDM2-mediated degradation of p53.
RPS7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 218 amino acids (1-194 a.a.) and having a molecular mass of 24.7kDa.RPS7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RPS7: Required for rRNA maturation. Defects in RPS7 are the cause of Diamond-Blackfan anemia type 8 (DBA8). DBA8 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S7e family. |
| UniProt Protein Details: | Protein type:Ribosomal; Translation Chromosomal Location of Human Ortholog: 2p25 Cellular Component: small subunit processome; focal adhesion; membrane; cytoplasm; nucleolus; ribosome; microtubule organizing center; cytosol; ribonucleoprotein complex; nucleus Molecular Function:protein binding; structural constituent of ribosome; RNA binding Biological Process: SRP-dependent cotranslational protein targeting to membrane; translation; viral reproduction; translational termination; viral infectious cycle; ribosomal small subunit biogenesis and assembly; translational elongation; cellular protein metabolic process; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; rRNA processing Disease: Diamond-blackfan Anemia 8 |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62081 |
| NCBI GenInfo Identifier: | 49065831 |
| NCBI Gene ID: | 6201 |
| NCBI Accession: | P62081.1 |
| UniProt Secondary Accession: | P62081,P23821, P24818, Q57Z92, Q6IPH1, |
| UniProt Related Accession: | P62081 |
| Molecular Weight: | 194 |
| NCBI Full Name: | 40S ribosomal protein S7 |
| NCBI Synonym Full Names: | ribosomal protein S7 |
| NCBI Official Symbol: | RPS7�� |
| NCBI Official Synonym Symbols: | S7; DBA8�� |
| NCBI Protein Information: | 40S ribosomal protein S7 |
| UniProt Protein Name: | 40S ribosomal protein S7 |
| Protein Family: | Ribosomal protein |
| UniProt Gene Name: | RPS7�� |
| UniProt Entry Name: | RS7_HUMAN |
