Human S100A7 Recombinant Protein (RPPB4562)
- SKU:
- RPPB4562
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P31151
Description
| Product Name: | Human S100A7 Recombinant Protein |
| Product Code: | RPPB4562 |
| Size: | 20µg |
| Species: | Human |
| Target: | S100A7 |
| Synonyms: | S100 calcium-binding protein A7 (psoriasin 1), S100A7c, PSOR1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | S100A7 protein at 0.5mg/ml in 20mM Tris-HCl, pH-8, 0.1M NaCl, 1mM DTT and 30% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSNTQAERSI IGMIDMFHKY TRRDDKIDKP SLLTMMKENFPNFLSACDKK GTNYLADVFE KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q |
S100A7 is a member of the S-100 family of calcium binding proteins and is produced through a non-classical secretory pathway to the cytoplasm. S100A7 takes part in the regulation of several cellular courses, such as cell cycle, cell progression and cellular differentiation. S100A7 holds two EF-hand domains and is extremely upregulated in psoriatic epidermis, in addition to bladder squamous cell carcinoma and breast cancer tissue, signifying a probable part in carcinogenesis.
S100A7 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 121 amino acids (1-101) and having a molecular mass of 13.6 kDa.The S100A4 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | S100A7: is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21 Cellular Component: focal adhesion; endoplasmic reticulum; cytoplasm; extracellular region; nucleus; cytosol Molecular Function:RAGE receptor binding; protein binding; zinc ion binding; calcium ion binding Biological Process: keratinocyte differentiation; sequestering of metal ion; response to reactive oxygen species; epidermis development; innate immune response; response to lipopolysaccharide; angiogenesis; defense response to Gram-negative bacterium |
| NCBI Summary: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P31151 |
| NCBI GenInfo Identifier: | 172046820 |
| NCBI Gene ID: | 6278 |
| NCBI Accession: | P31151.4 |
| UniProt Secondary Accession: | P31151,Q5SY67, Q6FGE3, Q9H1E2, |
| UniProt Related Accession: | P31151 |
| Molecular Weight: | 101 |
| NCBI Full Name: | Protein S100-A7 |
| NCBI Synonym Full Names: | S100 calcium binding protein A7 |
| NCBI Official Symbol: | S100A7�� |
| NCBI Official Synonym Symbols: | PSOR1; S100A7c�� |
| NCBI Protein Information: | protein S100-A7; psoriasin 1; S100 calcium-binding protein A7 (psoriasin 1) |
| UniProt Protein Name: | Protein S100-A7 |
| UniProt Synonym Protein Names: | Psoriasin; S100 calcium-binding protein A7 |
| Protein Family: | Protein |
| UniProt Gene Name: | S100A7�� |
| UniProt Entry Name: | S10A7_HUMAN |
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