Description
| Product Name: | Human SCG3 Recombinant Protein |
| Product Code: | RPPB4588 |
| Size: | 20µg |
| Species: | Human |
| Target: | SCG3 |
| Synonyms: | Secretogranin III, secretogranin-3, SGIII. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The SCG3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFPKPGGS QDKSLHNREL SAERPLNEQI AEAEEDKIKK TYPPENKPGQ SNYSFVDNLN LLKAITEKEK IEKERQSIRS SPLDNKLNVE DVDSTKNRKL IDDYDSTKSG LDHKFQDDPD GLHQLDGTPL TAEDIVHKIA ARIYEENDRA VFDKIVSKLL NLGLITESQA HTLEDEVAEV LQKLISKEAN NYEEDPNKPT SWTENQAGKI PEKVTPMAAI QDGLAKGEND ETVSNTLTLT NGLERRTKTY SEDNFEELQY FPNFYALLKS IDSEKEAKEK ETLITIMKTL IDFVKMMVKY GTISPEEGVS YLENLDEMIA LQTKNKLEKN ATDNISKLFP APSEKSHEET DSTKEEAAKM EKEYGSLKDS TKDDNSNPGG KTDEPKGKTE AYLEAIRKNI EWLKKHDKKG NKEDYDLSKM RDFINKQADA YVEKGILDKE EAEAIKRIYS SL |
SCG3 belongs to the chromogranin/secretogranin family of neuroendocrine secretory proteins. Though, the function of SCG3 is unknown, Granins operate as precursors for biologically active peptides. Several granins are known to serve as helper proteins in sorting and proteolytic processing of prohormones.
SCG3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 472 amino acids (20-468) and having a molecular mass of 53.0kDa.SCG3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SCG3: 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q21 Cellular Component: cytoplasmic vesicle; extracellular region Biological Process: blood coagulation; platelet activation; platelet degranulation |
| NCBI Summary: | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q8WXD2 |
| NCBI GenInfo Identifier: | 46397796 |
| NCBI Gene ID: | 29106 |
| NCBI Accession: | Q8WXD2.3 |
| UniProt Secondary Accession: | Q8WXD2,Q96C83, Q96GE8, Q9Y6G7, A8K2B0, B3KQP6, B4DK99 F5H3R8, |
| UniProt Related Accession: | Q8WXD2 |
| Molecular Weight: | 26,909 Da |
| NCBI Full Name: | Secretogranin-3 |
| NCBI Synonym Full Names: | secretogranin III |
| NCBI Official Symbol: | SCG3�� |
| NCBI Official Synonym Symbols: | SGIII�� |
| NCBI Protein Information: | secretogranin-3 |
| UniProt Protein Name: | Secretogranin-3 |
| UniProt Synonym Protein Names: | Secretogranin III; SgIII |
| Protein Family: | Secretogranin |
| UniProt Gene Name: | SCG3�� |
| UniProt Entry Name: | SCG3_HUMAN |
