Human SENP8 Recombinant Protein (RPPB2266)
- SKU:
- RPPB2266
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96LD8
- Research Area:
- Enzymes
Description
| Product Name: | Human SENP8 Recombinant Protein |
| Product Code: | RPPB2266 |
| Size: | 20µg |
| Species: | Human |
| Target: | SENP8 |
| Synonyms: | SUMO/sentrin specific peptidase family member 8, DEN1, NEDP1, Protease cysteine 2 (NEDD8 specific), PRSC2, NEDD8-specific protease 1, HsT17512, Deneddylase-1, NEDD8 specific-protease cysteine 2, Sentrin/SUMO-specific protease SENP8. |
| Source: | Escherichia Coli |
| Physical Appearance: | SENP8 is supplied as a sterile filtered clear solution. |
| Formulation: | SENP8 protein 1mg/ml is supplied in 20mM Tris-HCL, pH-8, 0.1M NaCl, 1mM DTT and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS HSRSNSVHAK QVAEKLEAFL GRKGDKLAFV EEKAPAQQNS YDCGMYVICN TEALCQNFFR QQTESLLQLL TPAYITKKRG EWKDLITTLA KK |
SENP8 is a cysteine protease which belongs to the sentrin-specific protease family. SENP8 takes part in processing and deconjugation of the ubiquitin-like protein labeled, neural precursor cell expressed developmentally downregulated 8(NEDD8).
SENP8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-212) and having a molecular mass of 26.3 kDa.The SENP8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SENP8: Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. Belongs to the peptidase C48 family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.68; Protease Chromosomal Location of Human Ortholog: 15q23 Cellular Component: cytosol; nucleus Molecular Function:endopeptidase activity; NEDD8-specific protease activity; SUMO-specific protease activity Biological Process: protein desumoylation; protein deubiquitination |
| NCBI Summary: | This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q96LD8 |
| NCBI GenInfo Identifier: | 26006881 |
| NCBI Gene ID: | 123228 |
| NCBI Accession: | Q96LD8.1 |
| UniProt Secondary Accession: | Q96LD8,Q96QA4, |
| UniProt Related Accession: | Q96LD8 |
| Molecular Weight: | 24kDa |
| NCBI Full Name: | Sentrin-specific protease 8 |
| NCBI Synonym Full Names: | SUMO/sentrin peptidase family member, NEDD8 specific |
| NCBI Official Symbol: | SENP8�� |
| NCBI Official Synonym Symbols: | DEN1; NEDP1; PRSC2�� |
| NCBI Protein Information: | sentrin-specific protease 8 |
| UniProt Protein Name: | Sentrin-specific protease 8 |
| UniProt Synonym Protein Names: | Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP8�� |
