Human SETD7 Recombinant Protein (RPPB2272)
- SKU:
- RPPB2272
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WTS6
- Research Area:
- Enzymes
Description
| Product Name: | Human SETD7 Recombinant Protein |
| Product Code: | RPPB2272 |
| Size: | 50µg |
| Species: | Human |
| Target: | SETD7 |
| Synonyms: | Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, EC 2.1.1.43, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain-containing protein 7, Set9, SET7/9, SETD7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The protein containing 50mM Tris-HCl buffer (pH7.5), 0.2M NaCl, 5mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK |
Set 7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.
SETD7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 366 amino acids & having a molecular mass of 40.7 kDa. The SETD7 purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
| UniProt Code: | Q8WTS6 |
| NCBI GenInfo Identifier: | 25091217 |
| NCBI Gene ID: | 80854 |
| NCBI Accession: | Q8WTS6.1 |
| UniProt Secondary Accession: | Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3, |
| UniProt Related Accession: | Q8WTS6 |
| Molecular Weight: | 40,721 Da |
| NCBI Full Name: | Histone-lysine N-methyltransferase SETD7 |
| NCBI Synonym Full Names: | SET domain containing lysine methyltransferase 7 |
| NCBI Official Symbol: | SETD7�� |
| NCBI Official Synonym Symbols: | KMT7; SET7; SET9; SET7/9�� |
| NCBI Protein Information: | histone-lysine N-methyltransferase SETD7 |
| UniProt Protein Name: | Histone-lysine N-methyltransferase SETD7 |
| UniProt Synonym Protein Names: | Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9 |
| Protein Family: | Histone-lysine N-methyltransferase |
| UniProt Gene Name: | SETD7�� |
| UniProt Entry Name: | SETD7_HUMAN |
