Description
| Product Name: | Human SIVA1 Recombinant Protein |
| Product Code: | RPPB4697 |
| Size: | 20µg |
| Species: | Human |
| Target: | SIVA1 |
| Synonyms: | Apoptosis regulatory protein Siva isoform 1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP, SIVA, SIVA1, Siva-1, Siva-2 |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SIVA1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET |
SIVA1, also referred to asApoptosis regulatory protein Siva isoform 1, is a death domain-containing proapoptotic protein. It is known as glucocorticoid-induced TNFR family-related gene, and also as an intracellular ligand of CD27, which are both members of the TNFR family expressed on lymphoid cells. There isn�t much known about the signalling pathway underlying the Siva-induced apoptosis.SIVA1 expression is modulated in multiple pathological processes.
SIVA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1-175 a.a.) and having a molecular mass of 21.1 kDa. SIVA1 is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus Molecular Function:viral receptor activity; protein binding; zinc ion binding; metal ion binding; CD27 receptor binding Biological Process: entry of virus into host cell; inhibition of NF-kappaB transcription factor; activated T cell apoptosis |
| NCBI Summary: | This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15304 |
| NCBI GenInfo Identifier: | 31077008 |
| NCBI Gene ID: | 10572 |
| NCBI Accession: | O15304.2 |
| UniProt Secondary Accession: | O15304,Q96P98, Q9UPD6, |
| UniProt Related Accession: | O15304 |
| Molecular Weight: | 175 |
| NCBI Full Name: | Apoptosis regulatory protein Siva |
| NCBI Synonym Full Names: | SIVA1, apoptosis-inducing factor |
| NCBI Official Symbol: | SIVA1�� |
| NCBI Official Synonym Symbols: | SIVA; CD27BP; Siva-1; Siva-2�� |
| NCBI Protein Information: | apoptosis regulatory protein Siva; CD27-binding (Siva) protein |
| UniProt Protein Name: | Apoptosis regulatory protein Siva |
| UniProt Synonym Protein Names: | CD27-binding protein; CD27BP |
| Protein Family: | Apoptosis regulatory protein |
| UniProt Gene Name: | SIVA1�� |
| UniProt Entry Name: | SIVA_HUMAN |
