Human SPA17 Recombinant Protein (RPPB4796)
- SKU:
- RPPB4796
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15506
Description
| Product Name: | Human SPA17 Recombinant Protein |
| Product Code: | RPPB4796 |
| Size: | 10µg |
| Species: | Human |
| Target: | SPA17 |
| Synonyms: | CT22, SP17, SP17-1, Sperm surface protein Sp17, Cancer/testis antigen 22, Sperm autoantigenic protein 17, Sperm protein 17, SPA17. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SPA17 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSIPFSN THYRIPQGFG NLLEGLTREI LREQPDNIPA FAAAYFESLL EKREKTNFDP AEWGSKVEDR FYNNHAFEEQ EPPEKSDPKQ EESQISGKEE ETSVTILDSS EEDKEKEEVA AVKIQAAFRG HIAREEAKKM KTNSLQNEEK EENK |
SPA17 is a protein present at the cell surface. SPA17 was characterized by its participation in the binding of sperm to the zona pellucida of the oocyte. The central portion of SPA17 has carbohydrate binding motifs and likely takes part in cell-cell adhesion functions such as immune cell migration and metastasis.
SPA17 Human Recombinant produced in E. coli is a single polypeptide chain containing 174 amino acids (1-151) and having a molecular mass of 19.8kDa. SPA17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SPA17: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. |
| UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: membrane; cytoplasm Molecular Function:calmodulin binding Biological Process: binding of sperm to zona pellucida; single fertilization; spermatogenesis |
| NCBI Summary: | This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009] |
| UniProt Code: | Q15506 |
| NCBI GenInfo Identifier: | 2833264 |
| NCBI Gene ID: | 53340 |
| NCBI Accession: | Q15506.1 |
| UniProt Secondary Accession: | Q15506,Q9BXF7, B2R4F2, |
| UniProt Related Accession: | Q15506 |
| Molecular Weight: | 151 |
| NCBI Full Name: | Sperm surface protein Sp17 |
| NCBI Synonym Full Names: | sperm autoantigenic protein 17 |
| NCBI Official Symbol: | SPA17�� |
| NCBI Official Synonym Symbols: | CT22; SP17; SP17-1�� |
| NCBI Protein Information: | sperm surface protein Sp17; sperm protein 17; cancer/testis antigen 22 |
| UniProt Protein Name: | Sperm surface protein Sp17 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 22; CT22; Sp17-1; Sperm autoantigenic protein 17; Sperm protein 17 |
| Protein Family: | Sperm surface protein |
| UniProt Gene Name: | SPA17�� |
| UniProt Entry Name: | SP17_HUMAN |
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