Human SPINT2 Recombinant Protein (RPPB4806)
- SKU:
- RPPB4806
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43291
Description
| Product Name: | Human SPINT2 Recombinant Protein |
| Product Code: | RPPB4806 |
| Size: | 10µg |
| Species: | Human |
| Target: | SPINT2 |
| Synonyms: | DIAR3, FLJ45571, HAI-2, HAI2, Kop, PB, Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, Placental bikunin, SPINT2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | SPINT2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMADRER SIHDFCLVSK VVGRCRASMP RWWYNVTDGS CQLFVYGGCD GNSNNYLTKE ECLKKCATVT ENATGDLATS RNAADSSVPS APRRQDSEDH SSDMFNYEEY CTANAVTGPC RASFPRWYFD VERNSCNNFI YGGCRGNKNS YRSEEACMLR CFRQQENPPL PLGSK |
SPINT2 is a transmembrane protein acts as an inhibitor of HGF activator. SPINT2 inhibits plasmin, plasma and tissue kallikrein, and factor XIa. SPINT2 has two extracellular Kunitz domains that inhibit few serine proteases. SPINT2 is assumed tumor suppressor, mutations in SPINT2 leads to a congenital sodium diarrhea.
SPINT2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (28-197 a.a.) and having a molecular mass of 21.8kDa.SPINT2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SPINT2: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3); also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Inhibitor; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytoplasm; extracellular region; integral to membrane Molecular Function:serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: cell motility Disease: Diarrhea 3, Secretory Sodium, Congenital, With Or Without Other Congenital Anomalies |
| NCBI Summary: | This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | O43291 |
| NCBI GenInfo Identifier: | 13124550 |
| NCBI Gene ID: | 10653 |
| NCBI Accession: | O43291.2 |
| UniProt Secondary Accession: | O43291,O00271, O14895, Q5TZQ3, Q969E0, A8K667, B4DLU1 |
| UniProt Related Accession: | O43291 |
| Molecular Weight: | 252 |
| NCBI Full Name: | Kunitz-type protease inhibitor 2 |
| NCBI Synonym Full Names: | serine peptidase inhibitor, Kunitz type, 2 |
| NCBI Official Symbol: | SPINT2�� |
| NCBI Official Synonym Symbols: | PB; Kop; HAI2; DIAR3; HAI-2�� |
| NCBI Protein Information: | kunitz-type protease inhibitor 2; placental bikunin; serine protease inhibitor, Kunitz type, 2; hepatocyte growth factor activator inhibitor type 2 |
| UniProt Protein Name: | Kunitz-type protease inhibitor 2 |
| UniProt Synonym Protein Names: | Hepatocyte growth factor activator inhibitor type 2; HAI-2; Placental bikunin |
| Protein Family: | Kunitz-type protease inhibitor |
| UniProt Gene Name: | SPINT2�� |
| UniProt Entry Name: | SPIT2_HUMAN |
