Human TAF9 Recombinant Protein (RPPB2301)
- SKU:
- RPPB2301
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16594
- Research Area:
- Enzymes
Description
| Product Name: | Human TAF9 Recombinant Protein |
| Product Code: | RPPB2301 |
| Size: | 20µg |
| Species: | Human |
| Target: | TAF9 |
| Synonyms: | TAF9 RNA polymerase II TATA box binding protein (TBP)-associated factor 32kDa, TAFII32, AK6, CINAP, TAFII31, TAF2G, CGI-137, MGC1603, MGC3647, MGC5067, TAFIID32, Coilin-interacting nuclear ATPase protein, Transcription initiation factor TFIID 31/32 kDa subunit, STAF31/32, ATP-AMP transphosphorylase 6, h RNA polymerase II TBP-associated factor subunit G, CINAP, AD-004, CIP, adenylate kinase isoenzyme 6, adrenal gland protein AD-004, coilin interacting protein, MGC:1603, MGC:3647, MGC:5067, EC 2.7.4.3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | TAF9 Human solution (0.5mg/1ml) containing 20mM Trsi HCL pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MLLPNILLTG TPGVGKTTLG KELASKSGLK YINVGDLARE EQLYDGYDEE YDCPILDEDR VVDELDNQMR EGGVIVDYHG CDFFPERWFH IVFVLRTDTN VLYERLETRG YNEKKLTDNI QCEIFQVLYE EATASYKEEI VHQLPSNKPE ELENNVDQIL� KWIEQWIKDH NS |
TAF9 is a universal transcription factor which enables the preinitiation complex assembly by direct interactions with the TATA promoter element. TAF9 is a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs) and performs as a channel for regulatory signals.
TAF9 produced in E.Coli is a single, non-glycosylated polypeptide chain containing�192 amino acids (1-172.a.a) and having a molecular mass of 22.2kDa. TAF9 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TAFII31: a component of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is essential for mediating regulation of RNA polymerase transcription. TAFII31 binds to p53, the basal transcription factor GTF2B, and the acidic transactivator viral protein 16 (VP16). It is a coactivator for P53. |
| UniProt Protein Details: | Protein type:EC 2.7.4.3; Transcription initiation complex; DNA-binding; Acetyltransferase; Kinase, other Chromosomal Location of Human Ortholog: 5q13.2 Cellular Component: nucleoplasm; PCAF complex; transcription factor TFIID complex Molecular Function:protein binding; histone acetyltransferase activity; DNA binding; transcription activator binding; protein heterodimerization activity; p53 binding; transcription coactivator activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; viral reproduction; protein stabilization; RNA elongation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; negative regulation of apoptosis |
| NCBI Summary: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q16594 |
| NCBI GenInfo Identifier: | 2498981 |
| NCBI Gene ID: | 6880 |
| NCBI Accession: | Q16594.1 |
| UniProt Related Accession: | Q16594 |
| Molecular Weight: | |
| NCBI Full Name: | Transcription initiation factor TFIID subunit 9 |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor 9 |
| NCBI Official Symbol: | TAF9�� |
| NCBI Official Synonym Symbols: | TAF2G; TAFII31; TAFII32; MGC:5067; TAFII-31; TAFII-32; TAFIID32; STAF31/32�� |
| NCBI Protein Information: | transcription initiation factor TFIID subunit 9 |
| UniProt Protein Name: | Transcription initiation factor TFIID subunit 9 |
| UniProt Synonym Protein Names: | RNA polymerase II TBP-associated factor subunit G; STAF31/32; Transcription initiation factor TFIID 31 kDa subunit; TAFII-31; TAFII31; Transcription initiation factor TFIID 32 kDa subunit; TAFII-32; TAFII32 |
| Protein Family: | Transcription initiation factor |
| UniProt Gene Name: | TAF9�� |
| UniProt Entry Name: | TAF9_HUMAN |
