Human UBE2L6 Recombinant Protein (RPPB2385)
- SKU:
- RPPB2385
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14933
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2L6 Recombinant Protein |
| Product Code: | RPPB2385 |
| Size: | 25µg |
| Species: | Human |
| Target: | UBE2L6 |
| Synonyms: | RIG-B, UBCH8, MGC40331, UBE2L6, Ubiquitin/ISG15-conjugating enzyme E2 L6, Ubiquitin-protein ligase L6, Ubiquitin carrier protein L6, Retinoic acid-induced gene B protein. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein contains 20mM Tris pH-8, 0.1mM PMSF, 1mM DTT, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASM RVVKELEDLQ KKPPPYLRNL SSDDANVLVW HALLLPDQPP YHLKAFNLRI SFPPEYPFKP PMIKFTTKIY HPNVDENGQI CLPIISSENW KPCTKTCQVL EALNVLVNRP NIREPLRMDL ADLLTQNPEL FRKNAEEFTL RFGVDRPS |
UBE2L6 belongs to the E2 ubiquitin-conjugating enzyme family. UBE2L6 enzyme is very similar in its primary structure to the enzyme encoded by UBE2L3 gene. UBE2L6 catalyzes the covalent attachment of ubiquitin to other proteins. UBE2L6 functions in the e6/e6-ap-induced ubiquitination of p53/tp53.
UBE2L6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 188 amino acids (1-152 a.a.) & having a molecular mass of 21.7 kDa. The UBE2L6 is fused to a 36 amino acid His Tag at N-terminus and purified by standard chromatography techniques.
| UniProt Protein Function: | UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11q12 Cellular Component: cytosol Molecular Function:protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity Biological Process: modification-dependent protein catabolic process; ISG15-protein conjugation; cytokine and chemokine mediated signaling pathway; protein modification process; protein ubiquitination; innate immune response; negative regulation of interferon type I production |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | O14933 |
| NCBI GenInfo Identifier: | 239938941 |
| NCBI Gene ID: | 9246 |
| NCBI Accession: | O14933.4 |
| UniProt Related Accession: | O14933 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 L6 |
| NCBI Official Symbol: | UBE2L6�� |
| NCBI Official Synonym Symbols: | RIG-B; UBCH8�� |
| NCBI Protein Information: | ubiquitin/ISG15-conjugating enzyme E2 L6 |
| UniProt Protein Name: | Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| UniProt Synonym Protein Names: | Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6 |
| UniProt Gene Name: | UBE2L6�� |
| UniProt Entry Name: | UB2L6_HUMAN |
