The ITGB3BP Polyclonal Antibody (CAB14859) is a valuable tool for researchers studying ITGB3BP, a protein involved in cell adhesion and migration processes. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications.ITGB3BP, also known as integrin beta-3-binding protein, plays a crucial role in cell signaling pathways that regulate cell behavior, including adhesion and migration. By binding to ITGB3BP, this antibody enables researchers to detect and analyze the protein in various cell types, making it ideal for studies in cell biology, cancer research, and related fields.
Understanding the function of ITGB3BP is essential for unraveling its role in diseases such as cancer, cardiovascular disorders, and developmental abnormalities. This antibody provides researchers with a powerful tool to investigate the biological functions of ITGB3BP and its potential implications in disease pathology and therapeutic development.
Product Name:
ITGB3BP Rabbit Polyclonal Antibody
SKU:
CAB14859
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ITGB3BP (NP_055103.3).
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23421
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human liver using ITGB3BP Rabbit pAb (CAB14859) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
