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KIR2DL5B Antibody (PACO22383)

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SKU:
PACO22383
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$503

Description

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KIR2DL5B Antibody (PACO22383)

The KIR2DL5B Monoclonal Antibody (PAC022383) is a key tool for researchers studying KIR2DL5B, a member of the killer cell immunoglobulin-like receptor (KIR) family. This antibody, produced through hybridoma technology, has high specificity for detecting KIR2DL5B protein in human samples and is validated for use in various research applications, including immunofluorescence and flow cytometry.KIR2DL5B is an inhibitory receptor expressed on natural killer (NK) cells and certain T cells, playing a role in regulating immune responses.

Its involvement in immune surveillance and response to pathogens makes it an intriguing target for studies in immunology and infectious diseases. The KIR2DL5B Monoclonal Antibody allows for precise detection and analysis of KIR2DL5B expression in different cell populations, facilitating research into the mechanisms underlying immune function and dysregulation.

Antibody Name:KIR2DL5B Antibody (PACO22383)
Antibody SKU:PACO22383
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:100-1:500
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human KIR2DL5B.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescence analysis of A549 cells, using KIR2DL5B antibody.
Background:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Synonyms:Killer cell immunoglobulin-like receptor 2DL5B ; Killer cell immunoglobulin-like receptor 2DLX; CD158f2 antigen;
UniProt Protein Function:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.CautionThe KIR2DL5B gene is not directly represented on the GRCh38 primary reference genome assembly but on alternate loci of that assembly.
UniProt Protein Details:
NCBI Summary:Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NHK3
NCBI GenInfo Identifier:74760352
NCBI Gene ID:553128
NCBI Accession:Q8NHK3.1
UniProt Secondary Accession:Q8NHK3,B0L651
UniProt Related Accession:Q8NHK3
Molecular Weight:40,695 Da
NCBI Full Name:Killer cell immunoglobulin-like receptor 2DL5B
NCBI Synonym Full Names:killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B
NCBI Official Symbol:KIR2DL5B  
NCBI Official Synonym Symbols:KIR2DL5; KIR2DLX; KIR2DL5.2  
NCBI Protein Information:killer cell immunoglobulin-like receptor 2DL5B
UniProt Protein Name:Killer cell immunoglobulin-like receptor 2DL5B
UniProt Synonym Protein Names:CD158 antigen-like family member F2; Killer cell immunoglobulin-like receptor 2DLX; CD_antigen: CD158f2
Protein Family:
UniProt Gene Name:KIR2DL5B  
UniProt Entry Name:
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