The KLHDC8A Polyclonal Antibody (PAC037846) is a valuable tool for researchers studying KLHDC8A, a protein involved in cellular processes related to cancer and autoimmune disorders. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By targeting the KLHDC8A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of immunology and oncology.KLHDC8A, also known as Kelch domain-containing protein 8A, has been implicated in tumorigenesis and immune system dysfunction, making it a promising target for therapeutic interventions.
Research into the function of KLHDC8A is crucial for uncovering its role in disease progression and for developing novel treatment strategies for cancer and autoimmune conditions. The KLHDC8A Polyclonal Antibody provides researchers with a reliable tool for exploring the mechanisms underlying these pathological processes and potential therapeutic avenues.
Western blot. All lanes: KLHDC8A antibody at 0.5µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 39 kDa. Observed band size: 39 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO37846 at dilution of 1:100.
Background:
Cul3-RING ubiquitin ligase complex, protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Synonyms:
Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1), KLHDC8A
UniProt Protein Function:
KLHDC8A: Protein type: Unknown functionChromosomal Location of Human Ortholog: 1q32.1Molecular Function: ubiquitin-protein ligase activityBiological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
