The Adipor1 Polyclonal Antibody (CAB18045) is a valuable tool for researchers studying Adipor1, a key receptor involved in adiponectin signaling and metabolic regulation. This rabbit polyclonal antibody has been rigorously validated for use in a variety of research applications, including Western blotting and immunohistochemistry.Adipor1, also known as adiponectin receptor 1, plays a crucial role in mediating the beneficial effects of adiponectin, a hormone involved in regulating glucose and fatty acid metabolism. Dysregulation of the adiponectin-Adipor1 pathway has been linked to various metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases.
By specifically binding to Adipor1, this antibody enables researchers to detect and analyze the expression of this receptor in different cell types and tissues. Studying the role of Adipor1 in metabolic homeostasis and its potential as a therapeutic target for metabolic diseases is essential for advancing our understanding of these conditions and developing new treatments.
Product Name:
[KO Validated] ADIPOR1 Rabbit Polyclonal Antibody
SKU:
CAB18045
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 276-375 of human ADIPOR1 (NP_057083.2).
This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51094
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and ADIPOR1 knockout (KO) 293T cells, using ADIPOR1 antibody (CAB18045) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
