The ALDH3A2 Polyclonal Antibody (CAB19899) is a valuable tool for research involving ALDH3A2, an enzyme involved in the detoxification of aldehydes in the cornea and elsewhere in the body. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It binds to the ALDH3A2 protein, enabling detection and analysis in various cell types, making it a crucial tool for studies in ophthalmology, toxicology, and metabolism research.ALDH3A2, also known as aldehyde dehydrogenase 3A2, plays a crucial role in protecting the cornea from UV-induced oxidative stress by metabolizing toxic aldehydes.
Dysregulation of ALDH3A2 has been implicated in conditions such as Sjogren-Larsson syndrome, a rare inherited disorder characterized by skin abnormalities, intellectual disability, and a buildup of fatty aldehydes. Understanding the function of ALDH3A2 is essential for developing potential therapies for these conditions and for gaining insights into the role of aldehyde detoxification in various tissues throughout the body.
Product Name:
[KO Validated] ALDH3A2 Rabbit Polyclonal Antibody
SKU:
CAB19899
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-320 of human ALDH3A2 (NP_001026976.1).
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
224
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and ALDH3A2 knockout (KO) HeLa cells, using [KO Validated] ALDH3A2 Rabbit pAb (CAB19899) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
