The [KO Validated] HDAC1 Monoclonal Antibody (CAB19571) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, has been extensively validated for knockout (KO) studies, ensuring accurate and reproducible results in research applications such as immunofluorescence, immunoprecipitation, and chromatin immunoprecipitation (ChIP).HDAC1, a member of the histone deacetylase family, is essential for chromatin remodeling and gene expression control. Dysregulation of HDAC1 activity has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
This antibody is validated for use in IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
[KO Validated] HDAC1 Monoclonal Antibody
SKU:
CAB19571
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0050
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
HD1, RPD3, KDAC1, GON-10, RPD3L1, C1
Cellular Localization:
Nucleus.
Calculated MW:
55kDa
Observed MW:
Refertofigures
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Purification Method
Affinity purification
Gene ID
3065
RRID
AB_2862675
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Immunohistochemistry analysis of paraffin-embedded Mouse lung tissue using HDAC1 Rabbit mAb (CAB19571) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Mouse testis tissue using HDAC1 Rabbit mAb (CAB19571) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Rat colon tissue using HDAC1 Rabbit mAb (CAB19571) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Rat testis tissue using HDAC1 Rabbit mAb (CAB19571) at a dilution of 1:2000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining.
