The LAIR1 Antibody (CAB10120) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. Its ability to bind specifically to the LAIR1 protein enables accurate detection and analysis in various cell types, making it an excellent choice for investigations in immunology and cancer research.LAIR1, also known as the Leukocyte-associated immunoglobulin-like receptor-1, plays a crucial role in maintaining immune balance by regulating inflammatory processes and dampening immune reactions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
LAIR1 Antibody
SKU:
CAB10120
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CD305, LAIR-1, LAIR1
Positive Sample:
THP-1, HL-60, U-937
Cellular Localization:
Cell Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
31kDa
Observed MW:
40-60kDa
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
3903
RRID
AB_2757645
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using LAIR1 Rabbit pAb (CAB10120) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): HeLa Exposure time: 20s.
