The LCOR Antibody (PAC06166) is a polyclonal antibody developed for research involving LCOR, a protein known to be involved in transcriptional regulation and chromatin remodeling. This antibody is specifically designed to target LCOR in human samples and has been validated for use in Western blot applications. LCOR, also known as Ligand-Dependent Nuclear Receptor Corepressor, plays a crucial role in gene expression regulation and is implicated in various biological processes such as development, differentiation, and metabolism.
By targeting LCOR, researchers can gain insights into how this protein functions in different cellular contexts, making it an essential tool for studies in molecular biology and gene regulation.Understanding the role of LCOR can provide valuable information for diseases related to dysregulated gene expression, such as cancer and metabolic disorders. By studying the activity of LCOR, researchers can potentially uncover new therapeutic targets and develop treatments that target gene expression pathways.
Antibody Name:
LCOR Antibody (PACO61666)
Antibody SKU:
PACO61666
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Ligand-dependent corepressor protein (13-144AA)
Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate. All lanes: LCOR antibody at 4.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48, 45, 107 kDa. Observed band size: 48 kDa.
Background:
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
Synonyms:
Ligand-dependent corepressor, LCoR, Mblk1-related protein 2, LCOR
UniProt Protein Function:
LCOR: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 10q24Cellular Component: nucleusMolecular Function: DNA binding; transcription factor activity; transcription factor bindingBiological Process: transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
