The LHFPL5 Polyclonal Antibody (PAC052642) is a valuable tool for research involving LHFPL5, a protein that plays a crucial role in cell signaling and membrane protein interactions. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the LHFPL5 protein, this antibody allows for the detection and analysis of LHFPL5 in a variety of cell types, making it an ideal choice for studies in molecular biology and signal transduction.
LHFPL5 is a transmembrane protein that is known to interact with other proteins involved in cell signaling pathways, making it an essential component for understanding cellular communication and function. Research on LHFPL5 has implications in various fields, including neuroscience, developmental biology, and cancer research. By studying the role of LHFPL5 in different cellular processes, researchers can gain insight into its potential as a therapeutic target for diseases related to abnormal cell signaling.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO52642 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO52642 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO52642 at dilution of 1:100.
Background:
In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).
Synonyms:
LHFPL tetraspan subfamily member 5 protein (Lipoma HMGIC fusion partner-like 5 protein) (Tetraspan membrane protein of hair cell stereocilia), LHFPL5, TMHS
UniProt Protein Function:
LHFPL5: May function in hair bundle morphogenesis. Defects in LHFPL5 are a cause of deafness autosomal recessive type 67 (DFNB67). DFNB67 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the LHFP family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.31Cellular Component: apical plasma membrane; integral to membrane; stereocilium bundle tipBiological Process: ion transport; auditory receptor cell stereocilium organization and biogenesis; detection of mechanical stimulus involved in sensory perception of soundDisease: Deafness, Autosomal Recessive 67
UniProt Protein Details:
NCBI Summary:
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008]
