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Anti-LIPG Antibody (CAB1891)

SKU:
CAB1891
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-LIPG Antibody CAB1891
  • Metabolism Antibodies 2 Anti-LIPG Antibody CAB1891
€139 - €419
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Description

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Antibody Name:Anti-LIPG Antibody
Antibody SKU:CAB1891
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 251-500 of human LIPG (NP_006024.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 251-500 of human LIPG (NP_006024.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GCGL NDVL GSIA YGTI TEVV KCEH ERAV HLFV DSLV NQDK PSFA FQCT DSNR FKKG ICLS CRKN RCNS IGYN AKKM RNKR NSKM YLKT RAGM PFRV YHYQ MKIH VFSY KNMG EIEP TFYV TLYG TNAD SQTL PLEI VERI EQNA TNTF LVYT EEDL GDLL KIQL TWEG ASQS WYNL WKEF RSYL SQPR NPGR ELNI RRIR VKSG ETQR KLTF CTED PENT SISP GREL WFRK CRDG WRMK NETS PTVE LP
Gene ID:9388
Uniprot:Q9Y5X9
Cellular Location:Secreted
Calculated MW:39kDa/56kDa
Observed MW:60kDa
Synonyms:LIPG, EDL, EL, PRO719
Background:The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family.
UniProt Protein Function:LIPG: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - glycerolipid; Phospholipase; Secreted; EC 3.1.1.3; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: Golgi apparatus; extracellular space; cell surface; early endosome

Molecular Function:heparin binding; lipoprotein lipase activity; phospholipase A1 activity; phospholipase activity

Biological Process: cell proliferation; cholesterol homeostasis; reverse cholesterol transport; phospholipid catabolic process; regulation of lipoprotein metabolic process; lipid metabolic process; positive regulation of cholesterol transport; response to nutrient; phospholipid homeostasis

NCBI Summary:The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5X9
NCBI GenInfo Identifier:22001808
NCBI Gene ID:9388
NCBI Accession:Q9Y5X9.1
UniProt Secondary Accession:Q9Y5X9,Q6P9C8, Q6UW82, B0LPG6,
UniProt Related Accession:Q9Y5X9
Molecular Weight:500
NCBI Full Name:Endothelial lipase
NCBI Synonym Full Names:lipase, endothelial
NCBI Official Symbol:LIPG  
NCBI Official Synonym Symbols:EL; EDL; PRO719  
NCBI Protein Information:endothelial lipase; lipoprotein lipase H; endothelial cell-derived lipase
UniProt Protein Name:Endothelial lipase
UniProt Synonym Protein Names:Endothelial cell-derived lipase; EDL; EL
Protein Family:Endothelial lipase
UniProt Gene Name:LIPG  
UniProt Entry Name:LIPE_HUMAN
Anti-LIPG Antibody (CAB1891)Western blot analysis of extracts of various cell lines, using LIPG antibody (CAB1891) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-LIPG Antibody (CAB1891)Immunohistochemistry of paraffin-embedded rat kidney using LIPG antibody (CAB1891) at dilution of 1:200 (40x lens).

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