Description
MAPK8IP2 Antibody (PACO10382)
The MAPK8IP2 Polyclonal Antibody (PAC010382) is a valuable tool for researchers studying the MAPK8IP2 protein, which plays a key role in cellular signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the MAPK8IP2 protein, researchers can explore its functions in various cell types, making it an essential tool for investigations in molecular biology and cell signaling research.MAPK8IP2, also known as IB2, is involved in the regulation of MAP kinase signaling pathways, which are crucial for cell growth, differentiation, and apoptosis.
Understanding the role of MAPK8IP2 in these pathways provides insights into various biological processes and diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. By using the MAPK8IP2 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying these diseases and potentially identify novel therapeutic targets.
| Antibody Name: | MAPK8IP2 Antibody (PACO10382) |
| Antibody SKU: | PACO10382 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human MAPK8IP2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | mitogen-activated protein kinase 8 interacting protein 2;MAPK8IP2;IB2;JIP2;PRKM8IPL ; |
| UniProt Protein Function: | MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Activator Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: protein complex; cell soma; cytoplasm Molecular Function:MAP-kinase scaffold activity; protein binding; kinesin binding; beta-amyloid binding; protein complex binding; structural molecule activity; protein kinase binding; protein kinase activator activity Biological Process: nonassociative learning; regulation of synaptic transmission, glutamatergic; behavioral fear response; dendrite morphogenesis; MAPKKK cascade; mating behavior; signal complex assembly; social behavior; regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; positive regulation of protein kinase activity; JNK cascade; regulation of receptor activity; regulation of excitatory postsynaptic membrane potential |
| NCBI Summary: | The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13387 |
| NCBI GenInfo Identifier: | 6912492 |
| NCBI Gene ID: | 23542 |
| NCBI Accession: | NP_036456.1 |
| UniProt Secondary Accession: | Q13387,Q96G62, Q99771, Q9NZ59, Q9UKQ4, |
| UniProt Related Accession: | Q13387 |
| Molecular Weight: | 87,975 Da |
| NCBI Full Name: | C-Jun-amino-terminal kinase-interacting protein 2 isoform 1 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase 8 interacting protein 2 |
| NCBI Official Symbol: | MAPK8IP2Â Â |
| NCBI Official Synonym Symbols: | IB2; JIP2; PRKM8IPLÂ Â |
| NCBI Protein Information: | C-Jun-amino-terminal kinase-interacting protein 2; IB-2; islet-brain 2; JNK-interacting protein 2; homologous to mouse JIP-1; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2 |
| UniProt Protein Name: | C-Jun-amino-terminal kinase-interacting protein 2 |
| UniProt Synonym Protein Names: | Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2 |
| UniProt Gene Name: | MAPK8IP2Â Â |
| UniProt Entry Name: | JIP2_HUMAN |
