The Merlin Polyclonal Antibody is a valuable tool for researchers studying the CD300A protein, a key player in immune regulation and inflammation control. Raised in rabbits, this antibody is highly reactive with human samples and is validated for use in Western blot applications. By binding to the CD300A protein, researchers can accurately detect and analyze this molecule in various cell types, making it ideal for studies in immunology and cancer research.
CD300A, also known as an immune inhibitory receptor, is essential for maintaining immune homeostasis and regulating inflammatory responses. Its role in modulating immune function makes it a promising target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CD300A is critical for developing therapies that modulate immune responses effectively in these disease contexts.
Product Name:
Merlin Polyclonal Antibody
SKU:
CAB22558
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 347-595 of human Merlin. (NP_000259.1).
cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, early endosome, filopodium membrane, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle membrane
Calculated MW:
70kDa
Observed MW:
75kDa
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.
Purification Method:
Affinity purification
Gene ID:
4771
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Merlin antibody (CAB22558) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
