The Mouse CD62L Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, clone MEL-14, AGEL0632) is a powerful tool for research involving CD62L, a key cell surface molecule essential for lymphocyte migration and immune response regulation. This highly specific antibody, derived from mouse monoclonal sources, is conjugated with PERCP-Cyanine5.5 for efficient detection and analysis in flow cytometry applications.CD62L, also known as L-Selectin, plays a pivotal role in facilitating lymphocyte adhesion and migration to secondary lymphoid tissues, a critical step in immune surveillance and response. By targeting CD62L, researchers can gain insights into lymphocyte trafficking patterns, immune cell activation, and inflammatory response modulation.
This antibody enables precise detection of CD62L expression on cell surfaces, making it an invaluable tool for studies in immunology, inflammation, and autoimmune diseases.With its high specificity and sensitivity, the Mouse CD62L Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated) opens up exciting possibilities for investigating the intricate mechanisms of immune cell trafficking and activation. Researchers can utilize this antibody to unravel the complexities of immune system regulation and develop targeted therapies for various immune-related conditions.
L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG2a, κ
Isotype Control:
PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:
Liquid
Conjugation:
PerCP/Cyanine 5.5
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P18337
Gene ID:
20343
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.
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