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Purified Anti-Mouse CD80 Antibody [16-10A1] (AGEL0034)

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SKU AGEL0034
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Hamster
Isotype IgG
Clone 16-10A1
Conjugation Unconjugated
Applications FC
Applications IHC
Applications IP
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Description

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Purified Anti-Mouse CD80 Antibody [16-10A1]

The Mouse CD80 Monoclonal Antibody (16-10A1) is designed for research involving CD80, a crucial cell surface molecule implicated in immune activation and costimulation. This monoclonal antibody, produced in mice, is highly reactive with mouse samples and is validated for use in flow cytometry and immunohistochemistry applications. It binds specifically to the CD80 protein, enabling precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.CD80, also known as B7-1, plays a critical role in the activation of T cells and the modulation of immune responses by interacting with CD28 and CTLA-4 receptors. Its significance in immune response modulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The Mouse CD80 Monoclonal Antibody (16-10A1) is an essential tool for researchers aiming to understand the mechanisms of immune activation and develop therapies that enhance or suppress immune function.Understanding the activity of CD80 is crucial for developing targeted therapies that either harness the immune system to fight cancer or modulate it to treat autoimmune diseases. By providing accurate and reliable detection of CD80, this antibody supports comprehensive studies of immune pathways, contributing to the advancement of immunotherapy and the development of innovative treatments for immune-related diseases.

Product Title:Purified Anti-Mouse CD80 Antibody [16-10A1]
SKU:AGEL0034
Size:25µg, 100µg
Clone No:16-10A1
Synonyms:T-lymphocyte activation antigen CD80;Cd80;Activation B7-1 antigen;B7;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:Purified Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q00609
Gene ID:12519
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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