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Key Features

PE/Cyanine5 Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL1108)

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SKU AGEL1108
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone M1/70
Conjugation PE/Cy5
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Description

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PE/Cyanine5 Anti-Mouse/Human CD11b Antibody [M1/70]

The Mouse Human CD11b Monoclonal Antibody (PE-Cyanine5 Conjugated) - M1/70 (AGEL1108) offered by AssayGenie is a crucial tool for immunologists and researchers studying immune cell populations. This monoclonal antibody targets CD11b, a cell surface marker primarily found on monocytes, macrophages, and granulocytes in both mice and humans. The PE-Cyanine5 conjugation allows for fluorescent detection, enhancing the ability to analyze and sort CD11b-expressing cells using flow cytometry.CD11b is a key integrin involved in cell adhesion and migration, playing a pivotal role in inflammatory responses and tissue repair processes. By specifically binding to CD11b, this monoclonal antibody enables precise identification and quantification of myeloid cell subsets within complex cell populations.

Its validated performance in various assays ensures reliable and reproducible results, making it an essential tool for studies focusing on immune cell function, inflammation, and infection responses in both preclinical and clinical research settings.Overall, the Mouse Human CD11b Monoclonal Antibody (PE-Cyanine5 Conjugated) - M1/70 (AGEL1108) is a valuable asset for researchers investigating the intricate mechanisms of immune cell activation and function in health and disease, providing insights that could lead to the development of novel therapeutic approaches for a wide range of conditions, including inflammatory disorders, infectious diseases, and cancer.

Product Title:PE/Cyanine5 Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL1108
Size:25µg, 100µg
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE/Cyanine5 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

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