The MPP6 Polyclonal Antibody (PAC020845) is a valuable tool for researchers studying MPP6, a protein involved in RNA splicing and processing. This antibody, generated in rabbits, displays high reactivity with MPP6 in human samples and is validated for use in Western blot assays. By targeting the MPP6 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component in studies focusing on RNA biology and gene expression.MPP6 is a key player in RNA metabolism, playing a crucial role in the regulation of gene expression and RNA processing.
Its involvement in splicing mechanisms and RNA binding make it a promising target for research in fields such as molecular biology and genetics. By studying the function and localization of MPP6, researchers can gain valuable insights into the intricate processes governing gene regulation and RNA function, paving the way for advancements in biotechnology and medicine.
Antibody Name:
MPP6 Antibody (PACO20845)
Antibody SKU:
PACO20845
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human MPP6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20845(MPP6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20845(MPP6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).
Synonyms:
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
UniProt Protein Function:
VAM-1: a membrane-associated of the MAGUK family. Interacts with Lin7, which localizes to postsynaptic densities of neurons and epithelial cell-cell junctions.
UniProt Protein Details:
Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p15
Molecular Function:protein binding
NCBI Summary:
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
