The MPP6 Antibody (CAB10509) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific to MPP6 in human samples and has been validated for use in Western blot applications. By targeting MPP6, this antibody allows for the detection and analysis of this protein in various cell types, making it ideal for research in molecular biology and RNA splicing mechanisms.MPP6 is a key player in the regulation of RNA splicing processes, making it a crucial component in gene expression and protein production. Dysregulation of MPP6 has been linked to various diseases, including cancer and genetic disorders, highlighting the importance of studying its function.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
MPP6 Antibody
SKU:
CAB10509
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MPP6, VAM1, p55T, VAM-1
Positive Sample:
293T, SW480, K-562, Mouse brain, Mouse liver, Rat brain
Cellular Localization:
Membrane, Peripheral Membrane Protein.
Calculated MW:
61kDa
Observed MW:
61kDa
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).
Purification Method
Affinity purification
Gene ID
51678
RRID
AB_2758058
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using MPP6 Rabbit pAb (CAB10509) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
