The N-Myc/MYCN Monoclonal Antibody (CAB22174) is a valuable tool for researchers studying the N-Myc/MYCN protein, a key regulator of cell growth and differentiation. This monoclonal antibody, produced using state-of-the-art technology, is specifically designed for use in immunohistochemistry and Western blot applications. It is highly reactive with human samples and has been validated for use in a variety of cell types.The N-Myc/MYCN protein is known to play a crucial role in the development and progression of neuroblastoma, a type of cancer that affects the nervous system.
By targeting this protein, researchers can gain valuable insights into the mechanisms underlying cancer growth and potentially identify new therapeutic targets. The N-Myc/MYCN Monoclonal Antibody is an essential tool for any laboratory conducting research in the fields of cancer biology and molecular biology.
Product Name:
N-Myc/MYCN Monoclonal Antibody
SKU:
CAB22174
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human N-Myc/MYCN (NP_005369.2).
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4613
Clone Number:
ARC55211
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using N-Myc/MYCN Rabbit mAb (CAB22174) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
