The NKX2-6 Polyclonal Antibody (PACO01177) is a valuable tool for researchers studying the NKX2-6 protein, an important transcription factor involved in heart development. This antibody, raised in rabbits, shows high reactivity with human samples and has been validated for use in applications such as Western blotting.NKX2-6 is known to play a crucial role in regulating cardiac gene expression and heart morphogenesis. Dysregulation of NKX2-6 has been implicated in various congenital heart defects and cardiovascular diseases.
By targeting NKX2-6 with this antibody, researchers can better understand its function and potentially identify novel therapeutic strategies for heart-related disorders.This antibody enables precise detection and analysis of NKX2-6 protein levels in different cell types, providing valuable insights for cardiovascular research and developmental biology studies. With its specificity and reliability, the NKX2-6 Polyclonal Antibody is an essential tool for investigating the role of NKX2-6 in heart development and disease.
Antibody Name:
NKX2-6 Antibody
Antibody SKU:
PACO01177
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Nkx-2.6.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NKX2-6; NKX2F; Homeobox protein Nkx-2.6; Homeobox protein NK-2 homolog F
UniProt Protein Function:
NKX2-6: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Defects in NKX2-6 may be a cause of conotruncal heart malformations (CTHM). CTHM defines a group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Belongs to the NK-2 homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: nucleusMolecular Function: transcription factor activityBiological Process: atrial cardiac muscle cell development; cell differentiation; embryonic heart tube development; gut development; hypothalamus development; negative regulation of apoptosis; pericardium development; pharyngeal system development; positive regulation of cell proliferation; tongue development; transcription, DNA-dependent; ventricular cardiac muscle cell developmentDisease: Conotruncal Heart Malformations
UniProt Protein Details:
NCBI Summary:
This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011]
