The NLGN4X Polyclonal Antibody (CAB7986) is a valuable tool for research involving NLGN4X, a cell adhesion molecule that plays a role in synaptic function and communication in the brain. The antibody, generated in rabbits, shows high specificity towards human samples and has been validated for use in Western blot applications. By targeting the NLGN4X protein, this antibody allows for the detection and analysis of NLGN4X in various cell types, making it ideal for studies in neuroscience and neurodevelopmental disorders.
NLGN4X is a critical player in synapse formation and function, particularly in excitatory synapses, and is linked to neurodevelopmental conditions such as autism spectrum disorders. Research on NLGN4X can provide insights into synaptic plasticity, neural communication, and potential therapeutic targets for neurological disorders. By understanding the role of NLGN4X, researchers can uncover new avenues for treatment and intervention in brain-related conditions.
Product Name:
NLGN4X Rabbit Polyclonal Antibody
SKU:
CAB7986
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 697-816 of human NLGN4X (NP_065793.1).
Cell junction, Cell membrane, Single-pass type I membrane protein, postsynaptic cell membrane, postsynaptic density, synapse.
Calculated MW:
92kDa
Observed MW:
92kDa
This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
57502
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NLGN4X antibody (CAB7986) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
