The OSBPL2 Antibody (CAB14199) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific to OSBPL2 and has been validated for use in various applications, such as Western blotting and immunofluorescence.OSBPL2, also known as oxysterol-binding protein-related protein 2, plays a key role in lipid homeostasis and intracellular cholesterol trafficking. Dysregulation of OSBPL2 has been linked to diseases like atherosclerosis, metabolic disorders, and neurodegenerative diseases.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
OSBPL2 Antibody
SKU:
CAB14199
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
ORP2, ORP-2, DFNA67, DNFA67, OSBPL2
Positive Sample:
U-251MG, A-549, HepG2, HeLa
Cellular Localization:
Cytosol, Lipid Droplet.
Calculated MW:
55kDa
Observed MW:
56kDa
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
Purification Method
Affinity purification
Gene ID
9885
RRID
AB_2761059
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OSBPL2 Rabbit pAb (CAB14199) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
