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Key Features

PE/Cyanine7 Anti-Human CD28 Antibody [CD28.2] (AGEL2371)

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SKU AGEL2371
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone CD28.2
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Human CD28 Antibody [CD28.2]

The PE-Cyanine7 Anti-Human CD28 Antibody (CD28-2) offered by AssayGenie is a cutting-edge tool designed for researchers studying CD28, a crucial co-stimulatory molecule involved in T cell activation. This antibody, optimized for use in flow cytometry applications, specifically targets the CD28 protein found on the surface of human cells, enabling precise detection and analysis across various cell types.CD28 is a key regulator of T cell activation and function, playing a pivotal role in determining immune response outcomes.

By engaging with CD28, researchers can gain insights into pivotal signaling pathways and immune responses associated with conditions such as autoimmune disorders, infectious diseases, and transplantation.With its high specificity and reliability, the PE-Cyanine7 Anti-Human CD28 Antibody (CD28-2) from AssayGenie is an indispensable tool for scientists striving to elucidate the intricate mechanisms governing immune responses and develop innovative therapeutic strategies.

Product Title:PE/Cyanine7 Anti-Human CD28 Antibody [CD28.2]
SKU:AGEL2371
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CD28.2
Synonyms:PAS2;MNS;HGpMiX;GYPA;GPSAT;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P10747
Gene ID:940
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

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