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PE/GenieFluor 594 Anti-Mouse CD8a Antibody [53-6.7] (AGEL3028)

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SKU AGEL3028
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, κ
Clone 53-6.7
Conjugation PE/AF594
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Description

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PE/GenieFluor 594 Anti-Mouse CD8a Antibody [53-6.7]

The PE GenieFluor 594 Anti-Mouse CD8a Antibody (53-6.7) is a highly specific reagent designed for the detection of CD8a, a crucial cell surface marker involved in T cell immune responses. This antibody, validated for use in flow cytometry, immunofluorescence, and immunohistochemistry, binds specifically to CD8a molecules on mouse cells, enabling precise identification and analysis of CD8a-positive cell populations.CD8a, a co-receptor found on cytotoxic T cells and regulatory T cells, plays a pivotal role in antigen recognition and immune response regulation.

By targeting CD8a, researchers can accurately characterize T cell subtypes, monitor immune cell activation, and investigate immune-mediated diseases such as infections, autoimmune disorders, and cancer. The PE GenieFluor 594 Anti-Mouse CD8a Antibody offers high sensitivity and specificity, making it an invaluable tool for immunology studies and preclinical research aiming to elucidate the complex mechanisms governing immune responses in health and disease.

Product Title:PE/GenieFluor 594 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL3028
Size:50 Tests, 100 Tests, 200 Tests
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Genie Fluor 594 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Genie Fluor594
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

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