The IP3R Polyclonal Antibody (AB9802) is a valuable tool for researchers studying the inositol triphosphate receptor (IP3R), a crucial regulator of intracellular calcium signaling. This antibody, produced in rabbits, is highly specific to human IP3R and has been validated for use in Western blot and immunohistochemistry applications.The IP3R protein plays a key role in various cellular processes, including cell growth, proliferation, and apoptosis, making it a target of interest in cancer research and other fields. By detecting and analyzing IP3R expression in different cell types, this antibody allows for a deeper understanding of its function and potential implications for disease pathology.
With its high specificity and reliability in experimental settings, the IP3R Polyclonal Antibody is an essential tool for researchers investigating calcium signaling pathways and their impact on cellular physiology. Its application extends to various areas of study, from neuroscience to cancer biology, highlighting its versatility and importance in advancing scientific knowledge.
Product Name:
IP3R Polyclonal Antibody
SKU:
CAB21471
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1812-1911 of human IP3R (NP_001365381).
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
3708
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IP3R Rabbit pAb (CAB21471) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): A-431.Exposure time: 10s.
