The Phospho-NFκB2 (S870) Polyclonal Antibody (CABP0419) is a valuable tool for researchers studying the NF-κB pathway and its role in cell signaling and immune response. This antibody, raised in rabbits, specifically binds to the NFκB2 protein phosphorylated at serine 870, allowing for the detection and analysis of this key signaling molecule in various cell types.NF-κB is a transcription factor that plays a crucial role in regulating the expression of genes involved in inflammation, immune response, and cell growth. Phosphorylation of NFκB2 at serine 870 is known to influence the activity and function of NF-κB in the cell, making it an important target for research in areas such as immunology, cancer biology, and inflammatory diseases.
By using the Phospho-NFκB2 (S870) Polyclonal Antibody, researchers can gain insights into the mechanisms of NF-κB signaling and its role in disease pathology. This antibody is validated for use in Western blot applications with human samples, providing reliable and accurate results for further studies. Researchers can utilize this antibody to further their understanding of NF-κB signaling and its potential as a therapeutic target for various diseases.
Product Name:
Phospho-NF-κB2-S870 Rabbit Polyclonal Antibody
SKU:
CABP0419
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A phospho specific peptide corresponding to residues surrounding S870 of human NF-κB2
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4791
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from MDA-MB-435 cells, using Phospho-NF-κB2-S870 Rabbit pAb (CABP0419).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
