The POM121/POM121B/POM121C Antibody (PACO05836) is a versatile tool for researchers studying nuclear pore complex proteins. This polyclonal antibody is raised in rabbits and is highly reactive with human samples, making it ideal for Western blot applications. It specifically binds to the POM121/POM121B/POM121C proteins, allowing for their detection and analysis in various cell types.The POM121 protein family plays a critical role in nuclear pore complex assembly and function, facilitating the transport of proteins and RNA between the nucleus and cytoplasm. Dysregulation of POM121 proteins has been implicated in various diseases, including cancer and neurodegenerative disorders.
By studying the expression and localization of POM121/POM121B/POM121C proteins, researchers can gain insights into their roles in cellular processes and disease pathogenesis.This antibody is a valuable tool for immunology and cancer research, providing researchers with the means to investigate the function and regulation of POM121 proteins in different contexts. With its high reactivity and specificity, the POM121/POM121B/POM121C Antibody (PACO05836) is a reliable resource for advancing our understanding of nuclear pore complex biology.
Antibody Name:
POM121/POM121B/POM121C Antibody (PACO05836)
Antibody SKU:
PACO05836
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the C-terminal region of human POM121.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
POM121; KIAA0618; NUP121; POM121A; Nuclear envelope pore membrane protein POM 121; Nuclear envelope pore membrane protein POM 121A; Nucleoporin Nup121; Pore membrane protein of 121 kDa; POM121B; Putative nuclear envelope pore membrane prote
UniProt Protein Function:
POM121: a single-pass membrane protein that is an essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Stably associated with the NPC throughout interphase and with the endoplasmic reticulum during metaphase. Contains F-X-F-G repeats. Belongs to the POM121 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; NucleoporinChromosomal Location of Human Ortholog: 7q11.23Cellular Component: nuclear envelope; nuclear poreMolecular Function: nuclear localization sequence binding; nucleocytoplasmic transporter activity; protein binding; structural constituent of nuclear poreBiological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein import into nucleus; protein sumoylation; RNA export from nucleus; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
