The Polybromo-1 Polyclonal Antibody (CAB9878) is a valuable tool for researchers studying the Polybromo-1 protein, which plays a crucial role in chromatin remodeling and gene regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.Polybromo-1 is a key component of the SWI/SNF chromatin remodeling complex and is involved in regulating gene expression, DNA repair, and cell cycle progression. Dysregulation of Polybromo-1 has been implicated in various diseases, including cancer and developmental disorders. By targeting Polybromo-1 with this antibody, researchers can investigate its function in different cell types and explore potential therapeutic strategies targeting this protein.
This antibody is an essential tool for studies in molecular biology, cancer research, and developmental biology. It enables the detection and analysis of Polybromo-1 in various experimental settings, providing valuable insights into the mechanisms underlying chromatin remodeling and gene regulation. Researchers can leverage this antibody to advance our understanding of Polybromo-1 biology and its potential implications for human health and disease.
Product Name:
PBRM1 Rabbit Polyclonal Antibody
SKU:
CAB9878
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PBRM1 (NP_060783.3).
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.
Purification Method:
Affinity purification
Gene ID:
55193
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PBRM1 Rabbit pAb (CAB9878) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
