Interleukin-2(IL-2) is an interleukin; a type of cytokine signaling molecule in the immune system;belongs to the IL-2 family. T-cells produce a potent immunoregulatory lymphokine in response to antigenic or mitogenic stimulation. The interleukin-2 (IL-2)/IL-2R signaling pathway is important for T cell proliferation and other critical functions in the immune response. IL-2 stimulates growth and differentiation of B-cells; NK cells; lymphokine-activated killer cells; monocytes; macrophages and oligodendrocytes. The new study discovered that IL-2 mutant has decreased toxicity while achieving a greater anti-tumor effector immune cell response. Interleukin-2/IL-2 Recombinant Protein (Mutant) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Interleukin-2/IL-2 Recombinant Protein (Mutant) (RPES1629)
Measured in a cell proliferation assay using CTLL?2 mouse cytotoxic T cells. The specific activity of Recombinant Human IL-2 is ?1-107 IU/mg.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Thr153(L100F;R101D;L105V;I106V;I112F) is expressed with a 6His tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
16.5 kDa
AP Mol Mass:
16&18 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
