Recombinant Human MMP-9/CLG4B Protein (His Tag) (RPES8825)
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodelling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils, and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. The dramatic overexpression of MMP-9 in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention.
Product Name:
Recombinant Human MMP-9/CLG4B Protein (His Tag)
SKU:
RPES8825
Size:
20μg, 100μg, 500μg, 1mg
Species:
Human
Synonyms:
92 kDa gelatinase, 92 kDa type IV collagenase, CLG4B, GELB, Gelatinase B, MANDP2, MMP9, Matrix metalloproteinase-9
Tag:
N-His
Sequence:
Arg162-Arg440
Expression Host:
E.coli
Accession:
P14780
Purity:
> 95% as determined by reducing SDS-PAGE.
Endotoxin:
< 10 EU/mg of the protein as determined by the LAL method
Bio-Activity:
Not validated for activity
Form:
Lyophilized powder
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Storage:
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
