| UniProt Protein Function: | RGS12: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 4 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, misc.; GAPsChromosomal Location of Human Ortholog: 4p16.3Cellular Component: nuclear matrix; condensed nuclear chromosome; cytoplasm; nucleolus; plasma membrane; nucleusMolecular Function: receptor signaling protein activity; GTPase regulator activity; GTPase activator activityBiological Process: transcription, DNA-dependent; regulation of catalytic activity; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq] |
| UniProt Code: | O14924 |
| NCBI GenInfo Identifier: | 38327601 |
| NCBI Gene ID: | 6002 |
| NCBI Accession: | NP_937872.1 |
| UniProt Secondary Accession: | O14924,O14922, O14923, O43510, O75338, B1AQ30, B1AQ31 B1AQ32 |
| UniProt Related Accession: | O14924, Q147X0, Q3B858, Q506M0, Q56A82, Q69YN1, Q8WX95, Q8WX96, Q8WX97 |
| Molecular Weight: | 156,357 Da |
| NCBI Full Name: | regulator of G-protein signaling 12 isoform 1 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 12 |
| NCBI Official Symbol: | RGS12Â Â |
| NCBI Official Synonym Symbols: | DKFZp761K1617; DKFZp761K1817Â Â |
| NCBI Protein Information: | regulator of G-protein signaling 12; OTTHUMP00000115311; OTTHUMP00000115312; OTTHUMP00000151172; regulator of G-protein signalling 12 |
| UniProt Protein Name: | Regulator of G-protein signaling 12 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS12Â Â |
| UniProt Entry Name: | RGS12_HUMAN |
