The RILP Polyclonal Antibody (PAC061121) is a valuable tool for researchers studying the role of RILP in cellular processes and signaling pathways. RILP, or Rab interacting lysosomal protein, is involved in the regulation of endocytic trafficking and lysosome biogenesis. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.By targeting the RILP protein, this antibody enables researchers to detect and analyze RILP expression in various cell types, facilitating investigations into its function in intracellular transport and organelle dynamics.
Understanding the role of RILP is essential for unraveling its involvement in processes such as autophagy, phagocytosis, and signaling cascades.Given its implications in cellular homeostasis and disease pathways, RILP serves as a promising target for studies in cell biology, immunology, and neurology. The RILP Polyclonal Antibody offers researchers a reliable tool to explore the intricate mechanisms of RILP-mediated cellular functions, paving the way for potential therapeutic interventions in conditions associated with dysregulated endocytic pathways.
Antibody Name:
RILP Antibody (PACO61121)
Antibody SKU:
PACO61121
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:
Human
Immunogen:
Recombinant Human Rab-interacting lysosomal protein (307-385AA)
IHC image of PACO61121 diluted at 1:500 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
Synonyms:
Rab-interacting lysosomal protein, RILP
UniProt Protein Function:
RILP: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17p13.3Cellular Component: phagocytic vesicle membrane; protein complex; mitochondrion; lysosome; lysosomal membrane; late endosome membrane; late endosomeMolecular Function: protein binding; Rab GTPase bindingBiological Process: protein transport; endosome to lysosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II
UniProt Protein Details:
NCBI Summary:
This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]
